Abstract
Ascorbic acid is involved in the formation of nitrogen oxide in leukocytes of humans and animals. It is an important role of the AA in maintaining the immune status of the organism.
Highlights
It is established that Ascorbic acid (AA) performs several important functions in the body: -reducing properties of AA do her perfect kosubstrate in monooxygenize hydroxylation reactions in the biosynthesis of collagen, as well as in the reactions of hydroxylation, leading to education noradrenalin, serotonin, carnitin in animal brain. -as an oxidant, participates in the protection of both cytozolic and membrane component cells from oxidative damage by neutralizing the damaging action of peroxide radicals [1,2,3,4]
Human leukocytes obtained from peripheral blood of adult donors fax during natural sedimentation of blood at room temperature
The ESR spectra of leukocytes incubated for with AA, recorded EPR signal resulting from the nitrozilnymi complexes gem-NO with triplets splitting an = 17 gausses at g = 2.01 [9, 10, 19, 22]
Summary
It is established that Ascorbic acid (AA) performs several important functions in the body: -reducing properties of AA do her perfect kosubstrate in monooxygenize hydroxylation reactions in the biosynthesis of collagen (hydroxylation of prolin and lysine residues), as well as in the reactions of hydroxylation, leading to education noradrenalin, serotonin, carnitin in animal brain. -as an oxidant, participates in the protection of both cytozolic and membrane component cells from oxidative damage by neutralizing the damaging action of peroxide radicals [1,2,3,4]. Despite the large amount of researches is still functional role of Leukocyte cells type AA remains unknown. Human leukocytes obtained from peripheral blood of adult donors fax during natural sedimentation of blood at room temperature. The leukocyte suspensions were purged with argon for 5-7 min and incubated them in identical conditions at room temperature.
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