Abstract
AbstractApplication of conventional and ionic liquid (IL) solvents and reagents in the Hiyama cross‐coupling reactions using triazenes as coupling partners was investigated. The microwave‐assisted and Pd‐catalyzed reactions in ROH/HBF4, ROH/BF3 ⋅ Et2O and in [BMIM][X]/[BMIM(SO3H)][OTf]/[BMIM][F] proved effective and gave respectable isolated yields within minutes. The scope of the Hiyama coupling reaction with triazenes was investigated in these media. The IL reagents and solvents were successfully employed to develop stepwise and sequential/tandem Hiyama‐Suzuki (H−S) and Hiyama‐Heck (H−H) methods. Study of the scope of these transformations led to facile synthesis of libraries of biaryls, hetero‐biaryls, diphenylmethanes, styryl‐biphenyls, and a host of biphenyl‐appended heterocycles. The potential for the recycling/reuse of the IL solvents in the Hiyama reaction, and in stepwise and sequential transformations was also examined.
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