Aryl H-phosphonates. Part 11. Synthetic and 31P NMR studies on the formation of aryl nucleoside H-phosphonates †

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The formation of aryl H-phosphonate diesters from the corresponding nucleoside 3′-H-phosphonates and various phenols was investigated in detail using 31P NMR spectroscopy. The major reaction pathways of aryl nucleoside H-phosphonates under different experimental conditions have been identified and a general method for a clean and efficient generation of these valuable synthetic intermediates was developed.