Artificial plant cell walls as multi-catalyst systems for enzymatic cooperative asymmetric catalysis in non-aqueous media.

Luca Deiana,Cheuk-Wai Tai,Armando Córdova,Abdolrahim A Rafi,Jan-E Bäckvall,Veluru Ramesh Naidu

doi:10.1039/d1cc02878b

Luca Deiana, Cheuk-Wai Tai + Show 4 more

Open Access

https://doi.org/10.1039/d1cc02878b

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Abstract

The assembly of cellulose-based artificial plant cell wall (APCW) structures that contain different types of catalysts is a powerful strategy for the development of cascade reactions. Here we disclose an APCW catalytic system containing a lipase enzyme and nanopalladium particles that transform a racemic amine into the corresponding enantiomerically pure amide in high yield via a dynamic kinetic resolution.

Highlights

The construction of protein-derived artificial metalloenzymes for application in chemical synthesis in non-aqueous media is an important area of research that has attracted considerable attention.[10,11,12,13,14,15,16,17,18,19,20,21]
The metal of a heme enzyme may be replaced by a transition metal[16,17,18] or a transition metal may be introduced into the active site of the enzyme.10a,19,20 The development of heterogeneous artificial metalloenzyme systems based on dual enzyme/metal nanocatalysis was recently disclosed.[21]
We have focused on a multidisciplinary approach for the advancement of non-aqueous biocatalysis,[8,25] which is based on a synergistically combined platform of cellulose chemistry, nanocatalysis, and heterogeneous catalysis

Summary

Introduction

Artificial plant cell walls as multi-catalyst systems for enzymatic cooperative asymmetric catalysis in non-aqueous media† The assembly of cellulose-based artificial plant cell wall (APCW) structures that contain different types of catalysts is a powerful strategy for the development of cascade reactions.

Results

Conclusion