Abstract
The alarming increase in antibiotic resistance has motivated the search for alternative antimicrobial strategies. A study developed by Oliveira et al. (e00073-20) proposes an antivirulence approach to tackle infectious diseases. They show that a recombinant bacteriophage tailspike protein can be used to remove bacterial surface polysaccharides of Providencia stuartii, thereby making the bacterium susceptible to serum killing. Being antivirulence agents, tailspikes do not select for resistance, and thus they represent a promising antibacterial strategy.
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