Abstract
In adults, reactive arthritis (ReA) following Clostridium difficile-enterocolitis has been documented. In children, only one case of Clostridium difficile (C. difficile) associated ReA in a child has been reported. We now describe 2 other cases of ReA associated with C. difficile in children. The characteristics of ReA due to C. difficile appear to be similar in adults and children. Both children showed poly-arthritis after an episode of diarrhoea with positive stool cultures for C. difficile. Arthritis was asymmetrical with a self-limiting course. Nonsteroidal anti-inflammatory drug (NSAID) therapy was sufficient. One case is remarkable because of its prolonged course of ReA despite NSAID therapy, and its association with the presence of HLA B27 antigen.
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