Abstract
A SERIES OF 30 patients with cerebral gliomas has received intra-arterial infusion chemotherapy at our institution over the past 3 years. This is a brief report summarizing our techniques and the negative results thus far obtained. Methods Each patient had the ipsilateral internal carotid artery cannulated percutaneously with a No. 18 polyethylene catheter. Radiographic identification of its location was obtained in each instance. The catheter was filled with a heparin solution when not in use and flushed several times a day. A simple electric rotary pump delivered 1 cc/min of the drug solution during the infusion. Eighteen patients received mechlorethamine hydrochloride (nitrogen mustard) at a dose of 2 to 4 mg/day until a total of 25 to 30 mg had been administered. Simultaneously, 250 mg of sodium thiosulfate per milligram of HN2was administered intravenously to neutralize the HN2and thereby protected the hemopoietic system.1 Twelve patients
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