Abstract
Epidemiologic study has suggested that arsenic exposure is positively related to increased blood pressure. However, the underlying mechanism concerning interaction between genetic polymorphisms and arsenic exposure remains unclear. In present study, within 395 Chinese, the effects of interaction between arsenic exposure and CCM3 gene polymorphisms on elevation of blood pressure were probed by multiple Logistic regression models after adjusting for confounding factors. Firstly, we found that serum arsenic was positively associated with blood pressure, cholesterol, glucose and C-reactive protein. Then, adjusted for confounding factors of age, gender, smoking, alcohol consumption, BMI and degree of education, arsenic exposure incurred the hazard of increased systolic pressure and diastolic pressure, with odds ratios (ORs) being 1.725 and 1.425, respectively. Distinctly, we found that interactions between rs3804610* rs9818496, rs6784267*rs9818496, and rs3804610* rs6784267 variant genotype can increase significantly risks of SBP. Additionally, interactions between rs9818496, rs3804610 and rs6784267 genotypic variantions and arsenic exposure boosted the hazard of increased systolic pressure, with ORs being 1.496, 1.496 and 1.312. In conclusion, our fingdings suggest that As exposure of population can assist CCM3 polymorphism in elevating SBP.
Highlights
Cardiovascular disease (CVD) is a major cause of death worldwide and a lot of evidence indicates that environmental toxicant exposures can deeply influence on CVD risk
Our analyses revealed interactions between CCM3 polymorphisms and arsenic exposure boosted the hazards of increased systolic pressure in south chinese, and our results demonstrate that arsenic exposure assist CCM3 polymorphisms in elevating blood pressure
Multivariate Logistic regression analysis was conducted by setting blood pressure as the dependent variable, and setting blood arsenic and urinary arsenic exposure, CCM3 gene polymorphism rs9818496, rs3804610, and rs6784267 as independent variables
Summary
Cardiovascular disease (CVD) is a major cause of death worldwide and a lot of evidence indicates that environmental toxicant exposures can deeply influence on CVD risk. Recent study has linked arsenic exposure to increased preclinical indicators of CVD risk, including carotid intima media thickness, hypertension, and plasma markers of oxidative stress and endothelial dysfunction [4,5,6,7]. High blood pressure (BP) is a primary risk factor for cerebrovascular disease and coronary heart disease. Several epidemiologic studies have found increased prevalence of hypertension or increased systolic and diastolic blood pressure levels among residents whose water supply has high level of arsenic (>100 μg/L) [1, 4, 6, 9, 10]
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