Abstract
In order to study the effect of microwave irradiation over aromatic nucleophilic substitutions at atmospheric pressure and in a homogeneous medium, experiments with disubstituted-benzenes and the nucleophiles piperidine and potassium t-butoxide, in refluxing DMSO or DMF, were carried out. The aromatic nucleophilic substitutions under microwave irradiation were 2.7 to 12 times faster than under conventional reflux. The aromatic nucleophilic substitutions in disubstituted-benzenes with the nucleophiles piperidine and potassium t-butoxide were carried out under microwave irradiation at atmospheric pressure and in a homogeneous medium. The rate of microwave assisted reaction under reflux was 2.7 – 12 times faster than the rate of reaction under conventional reflux conditions.
Published Version
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