Abstract
Aripiprazole (10 mg/day), when given to a 16 year old boy with solvent dependence, he developed rare movement disorder, ‘rabbit syndrome’.
Highlights
Aripiprazole (10 mg/day), when given to a 16 year old boy with solvent dependence, he developed rare movement disorder, ‘rabbit syndrome’
‘Rabbit syndrome’ is an uncommon drug-induced extrapyramidal syndrome (EPS) characterised by rapid chewing movements similar to those made by rabbits, ordinarily faster and more regular than the orofacial tic of tardive dyskinesia; the tongue is spared [1]
The development of EPS and akathisia with aripiprazole was notable in most studies, though few studies showed development of tardive dyskinesia [3,4] and neuroleptic malignant syndrome [5]
Summary
‘Rabbit syndrome’ is an uncommon drug-induced extrapyramidal syndrome (EPS) characterised by rapid chewing movements similar to those made by rabbits, ordinarily faster and more regular than the orofacial tic of tardive dyskinesia; the tongue is spared [1]. His mother noticed changes in his behaviour He communicated less with people, slept for long hours, used to get irritated there were frequent anger outbursts, increased craving for the substance, verbally abusive at times, and increased demand for money. Problems (ICD-10) criteria [7] He was admitted in the Department of Psychiatry of Gauhati Medical College Hospital, Guwahati and in the ward, he got aggressive, irritable, verbally and physically abusive towards mother. He was started on tab aripiprazole 10 mg once daily dosage. Drugs are evaluated individually for causality, and points deducted if another factor may have resulted in the adverse event, thereby weakening the causal association [8] (Table 1)
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