Abstract
The changes in arginine metabolism in liver and plasma were studied through short-term treatment with carbon tetrachloride. There was a considerable decrease in liver arginase at 24 hr and this may be partly related to the rupture of lysosomes and the release of proteolytic enzymes. Both arginase and ornithine carbamyl transferase were released into plasma from the necrosed liver cell. Elevated plasma arginase seems to act on plasma arginine, bringing about changes in arginine related metabolites in liver and plasma. Nonetheless, the net urea production in liver was not affected.
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