Abstract
Therapeutic guidelines and public health strategies for controlling Neisseria gonorrhoeae rely heavily on antimicrobial resistance (AMR) surveillance data.1–3 Historically, many international AMR surveillance reports have collected AMR data exclusively from males.4–9 Given the data suggesting that N gonorrhoeae clones circulating in men who have sex with men versus heterosexual populations potentially differ,10 we investigated differences in susceptibility based on sex.
Highlights
Therapeutic guidelines and public health strategies for controlling Neisseria gonorrhoeae rely heavily on antimicrobial resistance (AMR) surveillance data.[1,2,3] Historically, many international AMR surveillance reports have collected AMR data exclusively from males.[4,5,6,7,8,9] Given the data suggesting that N gonorrhoeae clones circulating in men who have sex with men versus heterosexual populations potentially differ,[10] we investigated differences in susceptibility based on sex
Significant differences in proportional resistance and proportional decreased susceptibility were identified from gonococcal isolates derived from males versus females for all antimicrobial classes assessed
For both penicillin and ciprofloxacin, resistance was predominantly higher in females versus males, with cumulative proportional resistance in females 1·35 times higher for penicillin; and 1·2 times higher for ciprofloxacin
Summary
Therapeutic guidelines and public health strategies for controlling Neisseria gonorrhoeae rely heavily on antimicrobial resistance (AMR) surveillance data.[1,2,3] Historically, many international AMR surveillance reports have collected AMR data exclusively from males.[4,5,6,7,8,9] Given the data suggesting that N gonorrhoeae clones circulating in men who have sex with men versus heterosexual populations potentially differ,[10] we investigated differences in susceptibility based on sex. Surveillance of a cohort of 14 312 gonococcal clinical isolates from New South Wales, Australia, derived from the Australian Gonococcal Surveillance Programme from 2015 to 2019 were analysed.
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