Antimicrobial resistance: a top ten global public health threat.

Eclinicalmedicine Eclinicalmedicine

doi:10.1016/j.eclinm.2021.101221

Abstract

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Antimicrobial resistance: a top ten global public health threat.

Highlights

antimicrobial resistance (AMR) occurs when microbes, such as bacteria, viruses, fungi, and parasites, adapt over time and no longer respond to drugs to which they were initially sensitive, making infections harder to treat and resulting in an increased risk of disease spread, and severe illness and death following routine medical procedures such as surgery
In 2019, the Interagency Coordination Group on Antimicrobial Resistance estimated that drug-resistant diseases are responsible for at least 700 000 deaths globally per year, a figure that could potentially increase to 10 million deaths globally per year by 2050
Hospitals remain a key site for the transmission of antimicrobial-resistant bacteria, emphasising the importance of good hygiene and infection prevention and control protocols as well as evidence-based consideration of the appropriate prescribing of antimicrobials

Summary

Introduction

An example of the latter is antimicrobial resistance (AMR), which was reported shortly after the introduction of the first effective antimicrobial agent and has been declared as one of the top ten global public health threats facing humanity by WHO in 2019. AMR occurs when microbes, such as bacteria, viruses, fungi, and parasites, adapt over time and no longer respond to drugs to which they were initially sensitive, making infections harder to treat and resulting in an increased risk of disease spread, and severe illness and death following routine medical procedures such as surgery.

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