Abstract
ABSTRACT Background:One of the most important concerns on health is the increased rates of obesity in population and the speed in which this number is increasing. This number translates a serious public health problem, since it also increases the risk of several other diseases associated with obesity resulting in significant morbidity and mortality. Among them, it seems to be connected to several neoplasms, such as colorectal carcinoma. Aim:To evaluate the impact of obesity as a risk factor for colorectal carcinoma through the detection of adenoma, and to discuss the mechanisms that could establish a link between obesity and neoplasm. Methods:Patients who underwent colonoscopy were included. Personal and anthropometric data, clinical history, and results of the tests were analyzed in order to verify the correlation of BMI and the presence of adenomatous polyps. Results:A total of 142 patients were studied, which a mean age of 62 years. Of the patients, 74 (52.1%) were men and 68 (47.9%) were. Obesity was identified in 16.2% of the patients. Polyps were found in 61 (42.9%), mostly smaller than 1 cm. Obese individuals were 1.56 times more likely to present colorectal adenoma than patients with normal weight. Conclusion:This study, although showing the greater presence of colorectal adenomas in obese individuals, did not show a significant difference in the occurrence of pre-malignant lesions.
Highlights
Affecting approximately one million people a year, colorectal cancer (CRC) is one of the biggest health problems worldwide
In view of the increasing prevalence of obesity[17,27] and the high incidence and mortality of CRC, the objective of this study was to evaluate the association between obesity and the development of adenoma, a precursor lesion for colorectal cancer, since the accumulation of excess fat consists of a risk factor potentially modifiable through prevention strategies
There were no complications in relation to colonoscopy or the anesthetic procedure
Summary
Affecting approximately one million people a year, colorectal cancer (CRC) is one of the biggest health problems worldwide. It is a common affection in developed countries and its incidence has progressively increased in undeveloped countries[6]. Only one in 100-200 adenomas will turn out to be malignant, all adenocarcinomas of the large intestine appear in a dysplastic epithelium. Based on this theory, it is reasonable to consider that adenomas and carcinomas must have similar epidemiological characteristics and share a common etiology. In view of the increasing prevalence of obesity[17,27] and the high incidence and mortality of CRC, the objective of this study was to evaluate the association between obesity and the development of adenoma, a precursor lesion for colorectal cancer, since the accumulation of excess fat consists of a risk factor potentially modifiable through prevention strategies
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