Abstract
Since its original description by Druckrey (1), the rodent model of colon cancer induced with i,2dimethylhydrazine has become widely used in the study of colonic carcinogenesis. At present, colonic tumors induced by DMH, Or its metabolites, azoxymethane (AOM) or methylazoxymethanol (MAM), are the most popular experimental models of colon cancer. It is, therefore, appropriate to question whether the DMH animal models are relevant to human colon cancer. In order to answer this question we must actually ask two more specific questions. First, do the tumoi's induced by DMH or its metabolites have similar characteristics to those known for human colon cancers? While similarities in known characteristics of both DMH-induced and human colon cancers do not necessarily mean that other characteristics of the DMH models will hold for human colon cancer, major discrepancies in the features of DMH-induced cancer and human colon cancer would certainly make one more skeptical about the relevance of the DMH model to human disease. The second question we need to answer is whether the study of the animal model of colon cancer is more productive and more useful than the study of human colon cancer itself. After all, an animal model is only useful if it can provide more information than the human disease itself. IS THE DMH MODEL OF COLON CANCER SIMILAR TO HUMAN DISEASE?
Published Version
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