Abstract
Summary o 1. Fifteen aspirin formulations (including 11 commercial types) and various other salicylate preparations were compared primarily for intrinsic gastric ulcerogenicity in cold stressed rats — a sensitive model for determining potential ulcerogenic activity. Several buffered aspirins were notably just as ulcerogenic as aspirin suspensions. 2. High Na + -containing aspirin formulations were the least ulcerogenic of those examined but also exhibited the shortest duration of action as antipyretics when assayed against yeast-induced fever in rats. Incorporation of D-glucose with certain metabolizable bases (citrate, acetate) markedly reduced the ulcerogenic activity of aspirin. 3. Aspirin impurities, benorylate, several non-acetylated salicylates (e.g. diflunisal, diplosal) were compared for anti-inflammatory potency, antipyretic activity and gastric ulcerogenic. These results suggest that for non-analgesic use, salts of salicylic acid, diflunisal and diplosal would seem preferable to aspirin — conferring the same potential benefit (as anti-inflammatory/antipyretic drugs) but with lower gastric ulcerogenicity.
Published Version
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