Abstract
In this study, aqueous extract of propolis, which is a natural bee product, tested for treatment of recurrent aphthus stomatitis (RAS). A total of 40 patients with RAS divided into 4 groups. Each patient received one of following pre-prepared mouthwash:Group A received aqueous propolis extract at 1% concentration.Group B received aqueous propolis extract at 0.5% concentration.Group C received dexamethosone at 0.1% concentration.Group D received distilled water. (Control group).The study was double blind and the patient instructed to use the mouthwashes for 5 min 3 times daily.The results of study showed signi-ficant difference between groups in pain score assessed at day 2 of study. High percentage of no pain recorded in group A comparing to other groups. However at 5 days of drug therapy no significant diff-erence noticed among the groups regard-ing pain score.For assessment of healing after 5 days, although no significant difference noticed among the groups, group A repor-ted to show high percentage of complete healing comparing to other groups. Also groups A, B and C showed 50% healing of ulcer comparing to only 20% in patient on group D.In conclusion, aqueous propolis ext-ract at 1% concentration showed good percentage of early reduction of pain score and rapid healing of ulcer with minimal side effect and further studies on other extract and concentration may be reco-mmended.
Highlights
Recurrent aphthus stomatitis (RAS) is a disorder characterized by recurring ulcer confined to the oral mucosa in patient with no other signs of disease.[1]. It is associated with a significant pain interfering with eating and drinking that may last 1 week to 1 month depending on the type of ulcer.[2]. Its precise etiology not clear and several possible causes determined include; here-ditary, hematological deficiencies, psycho-logy, trauma and hormonal changes.[2,3,4]
This study aim to determine the effect of aqueous propolis extract from Sinjar City at 1% and 0.5% concentration on the pain associated with RAS as well as on its healing
Following verbal informed consent obtained from each patient on participation, each patient assigned randomly to one of the following groups: - Group A: The patient received aqueous propolis extract at 1% concentration as mouthwash. - Group B: The patient received aqueous propolis extract at 0.5% concentration as mouthwash. - Group C: The patient received dexamethasone elixir at 0.1% concentration as mouthwash. - Group D: The patient received distilled water as mouthwash
Summary
Recurrent aphthus stomatitis (RAS) is a disorder characterized by recurring ulcer confined to the oral mucosa in patient with no other signs of disease.[1]. Other preparations used include tetracycline mouthwash, doxymycin, diphenhydramine, levamisole, thalidomide, topical diclofenac, chlorhexidine and recently amlexanox oral paste.[3,4,5,6] Topical and systemic steroids had been tested to reduce non infectious inflammatory origin of the RAS, but the side effects of opportunistic candidal infection must not be ignored.[1, 2] overall current therapy don’t carry a significant effect on reducing pain associated with RAS as well as not enhance its healing and new treatment with minimal side effects are clinically needed.[2]. This study aim to determine the effect of aqueous propolis extract from Sinjar City at 1% and 0.5% concentration on the pain associated with RAS as well as on its healing
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