Aqueous extract of dioscorea opposita thunb. normalizes the hypertension in 2K1C hypertensive rats

Nurmuhammat Amat,Raziya Amat,Sajida Abdureyim,Parida Hoxur,Zulpiya Osman,Dolkun Mamut,Anake Kijjoa

doi:10.1186/1472-6882-14-36

Abstract

BackgroundDioscorea opposita Thunb. (Huai Shan Yao, DOT), a common staple food in China, has been used for more than 2000 years in traditional Chinese medicine (TCM) to treat different systemic diseases including hypertension. The objective of this study was to investigate the possible antihypertensive effects of the aqueous extract of (DOT) in renovascular hypertensive rats as well as the mechanism in reducing blood pressure.MethodsThe two-kidney one-clip (2K1C) Goldblatt model of renovascular hypertension was used in Wistar rats. Rats with captopril, low-dose DOT and high-dose DOT treated 2K1C groups for 6 weeks. The blood pressure, cardiac mass index (heart weight/body weight), plasma level of angiotensin-II (Ang-II), endothelin-1(ET-1), superoxide dismutase (SOD) and malondialdehyde (MDA) were evaluated.ResultsDOT significantly reduced mean systolic and diastolic blood pressure after treatment. DOT also significantly increased plasma SOD activity but decreased plasma MDA concentration. Renal function was improved with captopril and DOT. DOT reduced plasma Ang-II activity and plasma ET concentration. They couldalso significantly reduce the left ventricular hypertrophy and cardiac mass index.ConclusionsOur results suggest that DOT may have an antihypertensive effect on hypertension by inhibit ET-converting enzyme and antioxidant activity, which warrant further exploration.

Highlights

Dioscorea opposita Thunb. (Huai Shan Yao, DOT), a common staple food in China, has been used for more than 2000 years in traditional Chinese medicine (TCM) to treat different systemic diseases including hypertension
Due to the increasing concern about the influence of foods on health condition, we have investigated the effect of the aqueous extract of untreated control group (DOT) on hypertension
In the captopril- and DOTtreated groups, the blood pressure, which was initially the same as that of the hypertensive controls, decreased progressively over the course of the 6 weeks treatment (P < 0.05) and there was no difference between the two DOT dose groups (DOT-L and DOT-H)

Summary

Introduction

Dioscorea opposita Thunb. (Huai Shan Yao, DOT), a common staple food in China, has been used for more than 2000 years in traditional Chinese medicine (TCM) to treat different systemic diseases including hypertension. (Huai Shan Yao, DOT), a common staple food in China, has been used for more than 2000 years in traditional Chinese medicine (TCM) to treat different systemic diseases including hypertension. It is generally believed that an intake of the Chinese yam may be beneficial to improve the function of the spleen, stomach, kidney and lung As a result, it is used clinically for the treatment of poor appetite, chronic diarrhea, asthma, dry cough, frequent or uncontrollable urination, diabetes and emotional instability [8,9]. The water yam (Dioscorea alata L.), another species Shan yao has been shown to possess antihypertensive activity in hypertensive animal models [18], suggesting that consumption of fresh yam tubers has potential health benefits for human beings. Due to the increasing concern about the influence of foods on health condition, we have investigated the effect of the aqueous extract of untreated control group (DOT) on hypertension

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Conclusion