Abstract
Purpose: To investigate the probable antihypertensive effects of Gastrodia elata Bl. extract (GEBE) in renovascular hypertensive rats as well as the mechanism involved in blood pressure reduction.Methods: The two-kidney one-clip (2K1C) Goldblatt model of renovascular hypertension was used in Wistar rats. The 2K1C group rats were treated with captopril (40 mg/kg/day), low-dose GEBE (150 mg/kg/day) and high-dose of GEBE (300 mg/kg/day) for 6 weeks by intragastric administration. Systolic (SBP) and diastolic blood pressure (DBP) were measured by the tail-cuff method. Urine creatinine and urea levels of the rats were measured by enzyme-linked immunosorbent assay (ELISA). Superoxide dismutase (SOD) and malondialdehyde (MDA) levels were also evaluated.Results: In the captopril- and GEBE-treated groups, blood pressure decreased progressively over the course of the 6-week treatment period compared with that of the untreated (control) rats (p < 0.01). High-dose GEBE also significantly increased plasma SOD activity but decreased plasma MDA concentration (p < 0.05). Renal function improved following captopril and GEBE (300 mg/kg/day) treatment (p < 0.01).Conclusion: The results suggest that GEBE probably exerts an antihypertensive effect by inhibiting endothelin (ET)-converting enzyme and via its antioxidant activity.Keywords: Antihypertensive, Gastrodia elata, Goldblatt renovascular hypertension, Endothelin-1, Hypertrophy
Highlights
Hypertension is the most common risk factor for myocardial infarction, stroke, heart failure, arterial fibrillation, aortic dissection and peripheral arterial diseases
We describe, in the present paper, the anti-hypertensive effects of Gastrodia elata Bl. extract (GEBE), together with changes in biological parameters such as Superoxide dismutase (SOD) activity and MDA level, following the administration of GEBE to the renal hypertensive rat model
The levels of blood urea nitrogen (BUN) and serum creatinine (Scr) were significantly higher in the untreated model group compared to the other group (p < 0.05)
Summary
Hypertension is the most common risk factor for myocardial infarction, stroke, heart failure, arterial fibrillation, aortic dissection and peripheral arterial diseases. The 2K1C model, which exhibits a transient increase in the activity of RAS and a sustained rise in blood pressure, has been described as very close to human mature hypertension [6,7]. Hypertension in this model is primarily the result of an augmented total peripheral resistance and, in mild cases of renal artery stenosis, bilateral reduction in renalclearance function [8]. Differences were considered statistically significant at p < 0.05
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