Appraisals of Sero-detection of Treponema pallidum Antibodies IgG and IgM and CBC parameters among Spontaneous Recurrent Miscarriage in Women- Case-Control Study in Gezira State 2018

Abstract

Objectives: We determined Sero-detection of Treponema pallidum (IgG and IgM antibodies) using ELIZA techniques women with recurrent Miscarriage in Gezira state and appraisal of other risk factors.
 Methods: in this case-control, a hospital-based study conducted at Wad Madani teaching hospital Department of Obstetrics gynecological, Gezira State, Sudan. Ninety subjects were involved, 45 were women with recurrent Miscarriage, and controls were healthy pregnant women (no miscarriage). Serum Treponema pallidum antibodies were estimated by the ELIZA method.
 Results: Sero-detection of IgG and IgM antibodies by using ELIZA techniques, a total of 45 miscarriage women (cases) for IgM 6 (13.3%) were positive, and 39 (48.8%) were negative for Treponema pallidum by using ELISA techniques. A total of 45 non-miscarriage women (control) for IgM 4 (8.9%) were positive, and 41(91.1%) were negative For Treponema pallidum by using ELISA techniques. A total of 45 miscarriage women (cases) for IgG 13(28.9%) were positive, 32(71.1%) were negative. Furthermore, IgG for non-miscarriage, like IgM 4(8.9%), was positive, and 41(91.1%) were negative.
 Conclusion: Higher prevalence of Treponema pallidum IgG seropositivity among pregnant women who reported miscarriages compared to those who did not report miscarriages (p < 0.001) while no association between IgM seropositivity and pregnant women who reported miscarriages.