Abstract
The study of chemical-biological interrelationships reaches its most challenging levels of complexity and difficulty in human clinical investigation. Whether the objective is development of a new drug, better understanding of an old one, or further elucidation of life processes which normally or pathologically distribute, transform, and eliminate exogenous and endogenous chemical substances, there is no experimental subject more important and more complex than man. And since no experimental subject is more difficult to study systematically than man, there probably is no area of biology and medicine where computer science and technology are needed more, but exploited less, than in human clinical investigation.
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