Abstract
90 Y; 89 Zr; 97,103 Ru; 99m Tc Abstract The carrier free radioisotopes play a vital role in the rapidly emerging fields of science and technology, emphatically in the areas of biomedical sciences. Again, the carrier free radioisotopes of transition series elements have achieved special importance due to their favourable nuclear and chemical properties, either in material research or in biomedical applications. In the present review article, the beneficial uses of some carrier free radioisotopes of the second transition series elements such as 90 Y, 89 Zr, 97,103 Ru, 99m Tc, 101m Rh, 111 Ag, 107,109 Cd, etc. in the field of nuclear medicine has been discussed. Some probable routes for production of these radionuclides have also been indicated.
Highlights
In 1934, the remarkable discovery of artificial radioactivity by Irene and Frederic Joliot Curie had added the most important step in the journey of nuclear medicine
Apart from Nuclear Medicine, different imaging modalities such as Computerised Tomography using X -rays (CT scanning), Magnetic Resonance Imaging (MRI), Ultra Sound Scanning are used, the role of Nuclear Medicine has been proven to be vital in many areas
The predictions that Nuclear Medicine Imaging will become obsolete when MRI was introduced did not come true and the current trends are to use these modalities in conjunction with each other to obtain the maximum information
Summary
In 1934, the remarkable discovery of artificial radioactivity by Irene and Frederic Joliot Curie had added the most important step in the journey of nuclear medicine. Another important point regarding the applications of radiopharmaceuticals is that the radiation dose depend both on the physical characteristics of the radionuclides and biological behavior of the radiopharmaceuticals. The rich chemistry of the Transition Series elements, specially their variable oxidation states, ability to form various types of complexes with almost all types of ligands, is useful for making numerous radiolabeled compounds Conjunction of these physical and chemical properties made the carrier free radionuclides of Transition Series elements almost indispensable to medical sciences especially for in vivo applications. Some probable production routes of these radionuclides have been indicated in a tabular form (Table 2)
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