Applications of Polymeric Micelles for Drug Delivery

Abstract

Polymeric micelles have attracted more and more attention in the biomedical field due to their controlled synthesis and sustained drug release, where a diverse of different drug carriers based on the polymeric micelles have been developed in recent years. This research will analyze the application and development of polymeric micelles that derived from block copolymers in biomedicine. There are three processes in drug delivery of drug carriers prepared by polymeric micelles, including micellar drug loading, micellar drug release and targeted therapy. In the polymeric micelles system, the reason why the solubilization and stabilization of drugs are improved is that the hydrophobic interaction and forming of hydrogen bond between micelles-system and drugs. This research also gives basic mechanism for polymeric micelles for passive and active drug targeting. What makes micelles ideal hosts for hydrophobic anti-cancer drugs or other targeted drugs is the hydrophobic nature of its core. This can make the drug more stable. In addition, this research is written to cover the latest information on polymeric micelles and methods of synthesis for applications. The advantages and disadvantages of its use as a drug carrier are also included. And it highlights the conditions that polymeric micelles need to meet as specific delivery tools in various targeting situations.