Applications of plant-based nanomedicines for wound healing – An emerging paradigm for effective therapy

Abstract

Wound healing is well-organized but a cascade of complex biochemical and cellular process to revive the normal morphology and functioning of skin. There are several plant-derived active biocomponents which are known to have their applications in wound healing due their negligible side effects. Present wound healing therapies, techniques and products are not that efficient to recover the wounds without affecting skin morphology and function. The approach/technique is considered to be the ideal if it cures/heals the wound without affecting the normal functioning of the skin, without scar formation, inhibit bacterial infection, speeds up the healing mechanism and keep the wound moisturized. Nanotechnological-based approaches are developed to increase the efficacy of the drug as well as herbal/plant-based organic products through direct delivery to the target, enhanced bioavailability and biocompatibility, controlled release of drug and enhanced solubility. The following literature review is about the different plant-based nanomaterials, their role in wound healing and delivery of herbal drugs to site of infection. For this purpose, profound research has been done to discover how and why natural product-based nanomaterials are being used to cure wound. This review will tell you the mechanism of action of plant-based nanomaterials to heal the wound and the elimination of challenges which are usually faced during the wound healing process such as bacterial infection, biofilm formation that leads towards chronic wound. As compared to the classical therapies of wound healing, nanotechnological based methods keep the wound moisturized. Various plant-based nano-formulations show remarkable activity in wound healing and management and are considered to be the future of pharmaceuticals.