Abstract
Applications of Antisense Peptide Nucleic Acid in Biomedicine and Biosciences
Highlights
Peptide Nucleic Acids (PNAs) are synthetic mimics of DNA/ RNA [1] containing N-2-aminoethylglycine repeating units in place of sugar-phosphate backbone of DNA or RNA
Antisense PNA (APNA) was found to inhibit the over expression of microRNA-155 which is responsible for causing various diseases especially tumors
An encapsulated APNA conjugate was found to obstruct microRNA-155 over expression that resulted in finding of potential anticancer therapeutics [3]
Summary
Submission: October 26, 2017; Published: December 11, 2017 *Corresponding author: Anjali Gupta, Department of Chemistry, School of Basic and Applied Sciences, Galgotias University, Greater Noida, UP, India, Email: Peptide Nucleic Acids (PNAs) are synthetic mimics of DNA/ RNA [1] containing N-2-aminoethylglycine repeating units in place of sugar-phosphate backbone of DNA or RNA. Due to the absence of electrostatic repulsions, PNA/DNA duplexes are thermally more stable as compared to DNA/DNA double helix. The sequence selective nature and mismatch intolerance of PNA probes make them useful in biomedical and biosciences applications [2]. PNAs can be used as antisense agents that block the translation process and inhibit the synthesis of targeted protein. These antisense oligonucleotides are used to treat genetic mutations or different infections
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