Abstract
We investigate the use of superparamagnetic iron oxide nanoparticles as a contrast agent for the cerebral perfusion of unilateral middle cerebral artery (MCA) subtotal occlusion by magnetic resonance three-dimensional pseudo-continuous arterial spin-labelled imaging (3D-pCASL) dual-phase scanning technology for the application value of blood flow to evaluate the difference of cerebral perfusion between symptomatic and asymptomatic patients. We found through research that the biphasic 3D-pCASL technology can accurately detect cerebral perfusion blood flow in patients with subtotal middle cerebral artery occlusion. Asymptomatic patients have higher cerebral perfusion than symptomatic patients with collateral circulation superparamagnetic iron oxide nanoparticles. Phase (PLD) equal to 1.5 s is more sensitive than 2.5 s, and PLD = 2.5 s can accurately reflect secondary collateral circulation's compensation status.
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