Application value of laparoscopic sleeve gastrectomy in treating obesity

Abstract

Objective To investigate the clinical application value of laparoscopic sleeve gastrectomy (LSG) in treating obesity. Methods Clinical data of 10 obese patients undergoing LSG in Shanxi Dayi Hospital of Shanxi Medical University from February 2013 to February 2015 were retrospectively studied. The informed consents of all patients were obtained and the local ethical committee approval had been received. Among the 10 patients, 5 were males and 5 were females with an average age of (40±13) years old and an average BMI of (42±8) kg/m2. Body weight, BMI, percentage of excess body weight loss (EWL%), blood pressure, fasting plasma glucose (FPG), glycosylated hemoglobin A1c (HbA1c), fasting insulin, triglyceride (TG) and high density lipoprotein cholesterol (HDL-C) of these patients were collected before and 1, 6, 12, 18 months after operation. Comparisons of the data before and after operation were conducted using t test. Results One month after operation, the average BMI of the LSG patients was (40±6) kg/m2, which was significantly lower than (42±8) kg/m2 before operation (t=11.173, P<0.05); the FPG and HbA1c of the 5 patients with preoperative type 2 diabetes mellitus were (8.4±1.2) mmol/L and (6.7±0.5)% respectively, which were significantly lower than (10.1±1.5) mmol/L and (7.8±0.6)% before operation (t=7.611, 15.241, P<0.05); the fasting insulin of the 4 patients with preoperative hyperinsulinemia was (21.1±2.3) U/L, which was significantly lower than (26.4±2.3) U/L before operation (t=6.355, P<0.05); the systolic and diastolic pressure of the 8 patients with preoperative hypertension were (140±12) and (92±6) mmHg respectively, which were lower than (155±16) and (99±9) mmHg before operation (t=7.933, 4.931, P<0.05); and after that, all the above indexes kept the downtrend. Conclusion LSG has a reliable short-term effect on obesity, with a good improvement of obesity-related metabolic diseases, but its long-term effect and recurrence remain to be further investigated. Key words: Laparoscopic sleeve gastrectomy; Obesity; Obesity-related metabolic diseases