Laparoscopic sleeve gastrectomy for patients with type 2 diabetes mellitus

Abstract

Objectives To investigate the efficacy of laparoscopic sleeve gastrectomy(LSG)for patients of type 2 diabetes mellitus (T2DM). Methods Between Jun 2013 and Jun 2017, 39 T2DM patients were enrolled in this study and underwent LSG. The clinical data of all patients were collected. The fasting plasma glucose(FPG), glycosylated hemoglobin (HbA1c), C-peptide , fasting insulin (FINS), glucagon-like peptide-1(GLP-1) as well as BMI of all patients were measured before and at 1, 6 months after surgery. Results All patients underwent LSG surgery successfully. The mean levels of FPG, HbA1c, C-peptide, FINS and BMI of all patients decreased at 6 months after surgery respectively compared to those before surgery[(6.4±1.2 )mmol/L vs.(9.6±2.3) mmol/L, t=9.455, P=0.000; (6.0±0.7)% vs.(7.5±1.0)%, t=10.538, P=0.000; (2.7±2.2)ng/ml vs.(4.0±2.6) ng/ml, t=3.491, P=0.001; (9.2±6.3) μIU/L vs.(15.5±11.1) μIU/L, t=4.902, P=0.000; (32.0±6.1) kg/m2 vs.(41.0±7.5) kg/m2,t=10.826, P=0.000], however the mean GLP-1 of all patients increased after surgery compared to that before surgery[(4.0±2.1)pmol/L vs.(3.1±2.2) pmol/L, t=-4.242, P=0.000]. At 6 months after surgery, 32 patients achieved complete remission of T2DM, 5 patients gained partial remission of T2DM and 2 patients got no remission of T2DM. Conclusions LSG is effective for obesity patients as well as patients suffering from T2DM. Key words: Diabetes mellitus, type 2; Gastrectomy; Laparoscopes