Application value of detecting tumor supplied group of factors in the discovery, diagnosis and treatment of malignant tumors in the early stages

Abstract

目的 探讨肿瘤相关物质(TSGF)检测对恶性肿瘤的应用价值.方法采用TSGF快速诊断试剂盒,对不同人群进行检测,共2 123例,分设四组:恶性肿瘤组152例,良性肿瘤组32例,常见疾病组53例,健康体检组1 886例,并用化学发光法对恶性肿瘤组进行AFP、CEA联合检测.结果血清TSGF含量[阳性率(%)]:健康体检组为(54.60±6.91)U/ml(5.09%),常见疾病组为(58.91±13.35)U/ml(26.42%),良性肿瘤组为(54.14±9.51)U/ml(6.25%),恶性肿瘤组为(70.87±11.03)U/ml(73.03%),恶性肿瘤组TSGF含量和阳性检出率明显高于另三组(P＜0.01).TSGF检测敏感性为73.03%,特异性为94.91%,总诊断率为93.28%.在联合检测中TSGF的敏感性(73.03%)比AFP(13.16%)和CEA(34.21%)差异均有显著意义(P＜0.01).常见疾病组也有26.42%假阳性存在.结论TSGF检测是一种具有广谱性、灵敏性、特异性和简便性均较理想的肿瘤筛查指标。