Abstract
In this study, it was aimed to investigate the synthesis, characterization and drug release behaviors of organo-hydrogels containing pH-sensitive Agar (A), Glycerol (G), Sweet Almond oil (Wu et al. in J Mol Struct 882:107–115, 2008). Organo-hydrogels, which contained Agar, Glycerol and different amounts of Sweet Almond oil, were synthesized via the free-radical polymerization reaction with emulsion technique using glutaraldehyde or methylene bis acrylamide crosslinkers. Then, the degree of swelling, bond structures, blood compatibility and antioxidant properties of the synthesized organo-hydrogels were examined. In addition, Organo-hydrogels which loaded with Ceftriaxone and Oxaliplatin were synthesized with the same polymerization reaction and release kinetics were investigated. In vitro release studies were performed at media similar pH to gastric fluid (pH 2.0), skin surface (pH 5.5), blood fluid (pH 7.4) and intestinal fluid (pH 8.0), at 37 °C. The effects on release of crosslinker type and sweet almond oil amount were investigated. Kinetic parameters were determined using release results and these results were applied to zero and first-order equations and Korsmeyer-Peppas and Higuchi equations. Diffusion exponential was calculated for drug diffusion of organo-hydrogels and values consistent with release results were found.
Highlights
It has been hypothesized that fatty acid-based hydrophobic organogels will form a matrix suitable for long-term release of hydrophilic molecules
After the hydrogel added Sweet Almond Oil (SAO), the ID water absorption capacity approximately decreased in 40–52% for p(AG-m) and 27–60% for p(AG-g) the tap water absorption capacity decreased in 37–57% for p(AG-g) and 47–73% for p(AG-m). p(AG-gSAO)1 organo-hydrogel in DI water and ethanol/DI water medium swollen at a rate of about 83% and 77% of its dry mass, respectively. % S values of p (AG-g-SAO)1 organohydrogel in acetone and gasoline media were approximately 7.6% and 2.4%
The results achieved in the study were summarized as follows: Within the scope of the presented study, preparation of Agar, Glycerol and Sweet almond oil-based organo-hydrogels loaded synthesized with different cross-linkers (glutaraldehyde (G) or methylene bis acrylamide [37]) and release studies of different drugs such as ceftriaxone and Oxaliplatin were examined in vitro conditions
Summary
It has been hypothesized that fatty acid-based hydrophobic organogels will form a matrix suitable for long-term release of hydrophilic molecules. Organogels have advantages as a drug delivery system. Since drug carrier organo-hydrogels are not affected by moisture; Since they provide the drug to pass through the skin; as they are resistant to microbial contamination; they have many advantages. As a drug carrier of organo-hydrogels, the gelling and trapping procedures were quite simple and useful. The main components are contained 5.26–7% palmitic acid, 0.33–0.6% palmitoleic acid, 1.61–4.40% stearic acid, 65.33- 76.73% oleic acid, 17.36–25.17% linoleic acid, 0.44–0.64% myristic acid, 21.25–17.89% linoleic acid, 90.50- 92.1% unsaturated fatty acids, 7.61–11.48% saturated fatty acids ratio. There is a great deal of scientific research that sweet almond oil has anti-inflammatory, immune-enhancing and anti-hepatotoxicity effects and prevents the growth of primary and metastatic colon cancer cells [7,8,9,10]
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