Abstract
Objective To investigate the comparison of assisted reproductive outcome of two kinds of mild-stimulation methods in IVF of ovarian poor response patients.Methods The ovarian poor response patients in IVF/ICSI with a total of 60 cycles was retrospectively analyzed.According to the difference of the ovarian stimulation,the patients were divided into two groups:letrozole group:a total of 30 cycles and clomiphene citrate group:a total of 30 cycles.The general situation of the patients,Gn dosage and period,indicators associated with IVF lab and IVF outcome in the two groups were compared.Results Age,body mass index,infertility period,the basis of endocrine were not statistically different (P ＞ 0.05) in the two groups; Gn dosage and treatment period in clomiphene citrate was higher than that in letrozole group (P ＜ 0.05) ; Average numbers of oocytes retrieved,fertilization rate,cleavage rate,implantation rate,clinical pregnancy rate,abortion rate had no significant difference in the two groups (P ＞ 0.05).Conclusions Two kinds of mild-stimulation methods for the ovarian poor response patients are both effective.Letrozole could reduce the Gn dosage and single cycle treatment costs and have the same pregnancy rate compared with clomiphene citrate. Key words: In-vitro fertilization (IVF) ; Mild-stimulation; Ovarian poor response ; Clomiphene ; Letrozole
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