Miscarriage analysis on patients with poor ovarian response

Abstract

Objective To investigate the association of poor ovarian response(POR) to the quantity and quality of oocytes by analyzing the premature miscarriage in POR patients with successful pregnancy.Methods A total of 1371 pregnant women who received in vitro fertilization in Reproductive Medical Center,The Third Affiliated Hospital,Guangzhou Medical College,between January 2005 and April 2009 were recruited.Of whom 58 had POR and 1313 normal ovarian response (NOR).The general clinical conditions and miscarriage rate in respective age group were compared.Results Patients with POR were slightly advanced age [(33.2 ± 3.5) years vs (31.5± 3.8) years,P＜0.05],rcquired higher dose of gonadotropin yet were featured by a comparatively lower number of oocytes for extraction,embryos for transplantation and fertilization (all P＜0.05).Nonetheless,the between-group difference in the duration of infertility,proportion of primary infertility,the number of days requiring ovarian stimulation,the rate of fertilization and implantation did not reach statistical significance(all P＞0.05).A lower rate of multifetation was noted in patients with POR (15.5％ vs 34.1％,P＜0.05),of whom the rate of miscarriage did not differ significantly from those with NOR [20.7％ (12/58) vs 12.6％ (165/1313),P＞0.05].The rates of miscarriage in patients with POR (13.3％,26.9％ and 17.6％ for ≤30,31-35 and ≥36 age groups) did not differ considerably (P＞0.05) with those in patients with NOR (10.7％,13.8％ and 14.4％).Conclusions POR does not contribute significantly to increased rate of miscarriage.Diminished ovarian reserve,but not reduced quality of oocytes,constitutes the POR in patients who manage the pregnancy. Key words: Poor ovarian response; Abortion,spontaneous; Oocytes