Abstract
The present paper describes various application possibilities of high-performance thin-layer chromatography (HPTLC) for qualitative and quantitative toxicological-chemical analysis. Exemplified by 115 toxicological relevant drugs, a simple and fast two-dimensional HPTLC procedure is presented, suited for the undirected qualitative toxicological-chemical analysis. Here, we demonstrate that the separation performance can be increased significantly by identifying substances on the basis of the two migration distances together with the remission spectra maxima, measured with a HPTLC scanner (densitometer). The values calculated for the discrimination power and the identification power were found to be comparable with those of other chromatographic procedures, commonly used for toxicological-chemical analysis (high-performance liquid chromatography [HPLC], gas chromatography-mass spectrometry [GC-MS], and liquid chromatography-mass spectrometry [LC-MS]). While a scanner increases clearly the efficiency of qual...
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