Abstract
Tadalafil (TAD) is a selective phosphodiesterase type 5 inhibitor. It is utilized for the treatment of erectile dysfunction (ED) and pulmonary arterial hypertension (PAH). It enhances the sexual performance in males during copulation. It is recommended in the guidelines as first-line therapy, because of convenience, high efficacy and low rates of side effects. As a result of the importance of this phosphodiesterase inhibitor agent in the treatment of ED, this work aims to compile the published analytical methods reported so far in the literature, for determination of TAD in biological samples and pharmaceutical formulations. Techniques like UV-VIS spectrophotometry, spectrofluorimetry, high - performance liquid – chromatography (HPLC), high - performance thin - layer chromatography (HPTLC), gas chromatography – mass spectrometry (GC-MS), liquid chromatography – mass spectrometry (LC-MS) with electrospray ionisation have been used for analysis, while high-performance liquid chromatography methods have been used most extensively.
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