Abstract
Amitriptyline hydrochloride reacts in acidic medium with the thiocyanate complex of titanium (IV) forming a yellow ion- association compound, insoluble in water but fairly soluble in a mixture of chloroform and butyl alcohol (4:1). The formation and extraction conditions of the compound are described. The compound was characterized by UV, VIS, IR and 1H NMR spectrometry. The colored compound exhibits a maximum absorption at 360 nm. Under the optimum experimental conditions, amitriptyline hydrochloride was determined in the 3-60 μg/cm3 range with a relative standard deviation less than 0.5% (n=8). The proposed method was verified against the pharmacopoeial method and applied to the determination of amitriptyline hydrochloride in pharmaceuticals.
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