Abstract
Nowadays, it is becoming more evident that the biological activity attributed to polyphenols would be mainly due to the phenolic metabolites formed in the human body, rather than the original forms. Therefore, complete characterization of grape-derived phenolic products should also include the evaluation of their potential bioavailability. In the ISANH 2015 Congress, we presented the chemical composition of grape pomace extracts obtained under innovative processes. In this edition, we have applied a Dynamic Gastrointestinal Simulator (simgi®) to study the metabolism of those extracts and their impact on human colon microbiota. Ammonium, short chain fatty acids and main grape phenolic compounds and their metabolites, as well as main microbial groups were monitored in the digested samples. The results showed that feeding of the simgi® with these extracts (700 mg/day, 14 days) activated the metabolism of the colonic microbiota, producing some phenolic metabolites such as gallic acid, protocatechuic acid, 3-O-methylgallic, syringic acid, catechol, 3,4-dihydroxyphenylacetic acid, 3-hydroxyphenylacetic acid and 3-(3,4-dihydroxyphenyl)propionic acid, among others, as well as an increase in the proportion of butanoic acid. Concurrently, feeding of grape pomace extracts produced slight changes at microbiological level, mainly in the lactic acid bacteria group.
Published Version
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