Abstract
The Nim-2-adamantyloxycarbonyl (2-Adoc) group is suitable for the protection of the imidazole function of the histidine residue in peptide synthesis in terms of its stability to trifluoroacetic acid (TFA), tertiary amines and 1-hydroxybenzotriazole (HOBt), and its reduction of racemization rate during the coupling reaction.
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More From: Journal of the Chemical Society, Chemical Communications
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