Abstract
Application of surface plasmon resonance of citrate capped silver nanoparticles for the selective determination of some fluoroquinolone drugs
Highlights
Quinolones are a class of broad-spectrum antibiotics, which are active against both gram-positive and gram-negative bacteria
Citrate capped silver nanoparticles (Ag NPs) was used as a colorimetric probe for the sensitive determination of six drugs belongs to fluoroquinolone family (Ciprofloxacin, Lomefloxacin, Ofloxacin, Pefloxacin, Levofloxacin and Moxifloxacin)
The dramatic changes of the absorption spectra and solution color of citrate-capped Ag NPs on exposure to six fluoroquinolone drugs (Fig. 2) confirmed that the aggregation mechanism of AgNPs was caused by electrostatic interaction between negatively charged citrate stabilized particle surfaces and the positive charges of fluoroquinolone drug
Summary
Quinolones are a class of broad-spectrum antibiotics, which are active against both gram-positive and gram-negative bacteria. Pharmaceutical grade ciprofloxacin hydrochloride was supplied by Kahira Pharmaceuticals & Chemical Industries Company (Cairo, Egypt). Ofloxin tablets: (Kahira Pharmaceuticals & Chemical Industries Company, Cairo, Egypt) labelled to contain 200 mg Ofloxacin per tablet. Ciprocin eye drop: (the Egyptian International Pharmaceutical Industries Company EIPICO, Cairo, Egypt) labeled to contain 3 mg Ciprofloxacin per 1 ml solution. Maxaflox eye drop: (Pharaonia Pharmaceuticals Company, Alexandria, Egypt) labeled to contain 3 mg Lomefloxacin per 1 ml solution. Ofloxin eye drop: (Kahira Pharmaceuticals & Chemical Industries Company, Cairo, Egypt) labeled to contain 3 mg Ofloxacin per 1 ml solution. Lee-flox eye drop: (SEDICO Pharmaceutical Company, Giza, Egypt) labeled to contain 5 mg Levofloxacin per 1 ml solution. Venaxan injection for intravenous infusion: (SEDICO Pharmaceutical Company, Giza, Egypt) labeled to contain 500 mg Levofloxacin per 100 ml of solution for infusion. Boeco magnetic stirrer mms 3000 12 V. 300 mA 03000 1/min (Germany) and pH-meter, model AD11P (Adwa, Romania) were used
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