Application of recombinant epidermal growth factor gel on the nursing of superficial 2nd burn wound

Abstract

Objective To observe the therapeutic effect of recombinant epidermal growth factor gel on the nursing of superficial 2nd burn wound.Methods Totals of 50 patients with superficial 2nd burn were selected.By means of auto-control,different region of the same wound or symmetrical wounds were divided into observation group and control group.In the observation group,recombinant epidermal growth factor gel was mixed with silicone gel cream and was covered the wound humidly.The control group adopted silicone gel cream only to humidly covered wounds.Wound healing time,dressing change frequency,pain intensity and level of exudates in two groups were observed and analyzel.Results Average wound healing time in control group was ( 11.8 ± 1.7 ) days and ( 8.6 ± 1.6) days in observational group,and the difference was statistically significant ( t =-9.834,P＜0.05 ).Dressing frequencies in the observational group and control group respectively was (4.5 ± 0.9 ) and ( 6.1± 0.9 ) times,and the difference was statistically significant ( t =- 9.336,P ＜ 0.05 ).There was no significantly difference in the intensity of dressing pain,and the degree of exudates of 2nd time of dressing was detected between control group and observation group (P ＞ 0.05 ).While in the 3rd and 4th time of dressing,degree of exudates of observational group was significantly improved than that of the control group ( x2 =8.988,5.316 respectively; P ＜ 0.05 ).Conclusions Recombinant epidermal growth factor application can decrease exudates level and dressing changing frequency,and significantly improve epidermal regeneration so as to accelerate wound healing. Key words: Superficial 2nd burn; Recombinant epidermal growth factor; Exudates; Wound nursing