Application of non-invasive ventilation in treating COPD patients with respiratory failure

Abstract

Objective To evaluate the clinical value of early use of non-invasive ventilation in chronic obstructive pulmonary disease(COPD)patients with respiratory failure.Methods Totally 58 patients with COPD induced respiratory failure,admitted from January 2007 to June 2009,received BIPAP non-invasive ventilation treatment,and were retrospectively studied.The changes of respiration rate,heart rate,arterial blood gas before and after non-invasive ventilation application were compared.According to the application time of non-invasive ventilation,58 patients were divided into two groups:group Ⅰ(early application group,n=27)and group Ⅱ(non-early application group,n=31).The time to improve the symptoms,the application time of non-invasive ventilation,cure rate,tracheal intubation rate and mortality were compared between the two groups.Results Non-invasive ventilation was applied on 54 patierts effectively.Their respiratory rate,heart rate significantly decreased,PH,PaO_2 and SaO_2 significantly increased and PaCO_2 significantly decreased(P＜0.05).The tracheal intubation was performed in 4 patients.The time needed to improve the symptoms and the application time of non-invasive ventilation were significantly different between group Ⅰ and group Ⅱ(t=7.38,5.64,all P＜0.01).In group Ⅰ,all patients were cured,no tracheal intubation.In group Ⅱ,27 patients were cured,4 patients required tracheal intubation,and 2 died.Conclusion Non-invasive ventilation application is effective in the treatment of COPD patients with respiratory failure.Early application can increase the cure rate and reduce mortality. Key words: Pulmonary disease,chronic obstructive; Ventilators,mechanicai; Respiratory insufficiency