Application of mitogen-activated protein kinase inhibitor SP 600125 for wound healing control

Irina A Shurygina,Galina B Granina,Nikolay V Zelenin,Michael G Shurygin

doi:10.7243/2050-1218-2-9

Irina A Shurygina, Galina B Granina + Show 2 more

Open Access

https://doi.org/10.7243/2050-1218-2-9

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Abstract

Abstract Background: The problem of wound healing remains critical due to lack of methods for direct control of regeneration processes. Main purpose of the study: To investigate the ability to

Highlights

The problem of wound healing remains critical due to lack of methods for direct control of regeneration processes.Main purpose of the study: To investigate the ability to control wound healing process by inhibiting Jun N-terminal kinases (JNK) mitogenactivated protein kinase
It has been established that the application of Mitogen-Activated Protein Kinase (MAPK) inhibitor considerably affects marker expression of various fibroblasts, which increases the expression of marrow precursors in the focus, being indicative of a more active attraction of progenitor cells into connective tissue formation zone
In order to assess the effect of JNK MAPK inhibitors onto differentiation of fibroblasts in the focus of connective tissue formation, we investigated expression of marroworiginated cell markers (CD34), white blood cell markers (CD45), procollagen of type I (ColIAI), MMP9, as well as actin in fibroblasts at the wound healing zone

Summary

Introduction

The problem of wound healing remains critical due to lack of methods for direct control of regeneration processes.Main purpose of the study: To investigate the ability to control wound healing process by inhibiting JNK mitogenactivated protein kinase. The problem of wound healing remains critical due to lack of methods for direct control of regeneration processes. The problem of wound healing optimization remains critical due to lack of methods of direct control over regeneration processes. One of particular complications during the postoperative period is discrepancy related to healing problems. According to M.K. Cigdem et al, [2] discrepancy accounts for 0.2–1.2% of all complications in early post-operative period. Cigdem et al, [2] discrepancy accounts for 0.2–1.2% of all complications in early post-operative period Aside from problems related with wound contamination or surgical errors ((eruption of surgical sutures) (29%), infection (13%), combination of eruption of surgical sutures and infection (5%), as well as defects in surgical technique, e.g., suture defects (10%), loose knots (5%) [1], the definite cause of discrepancy may not be detected in 48% of all cases [1], which suggests presence of endogenic disorders of wound healing process.

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