Abstract
In the present study, a novel approach for surface characterization of ceramic biomaterials is proposed. Two ceramic biomaterials—hydroxyapatite and β-tricalcium phosphate—were examined by means of inverse liquid chromatography. The Abraham LFER model was applied for physicochemical characteristics of the surface. Different compounds, characterized by different polarity and different donor–acceptor properties of functional group, were used as test solutes. The chromatographic experiments were carried out with two compositions of the mobile phase: pure acetonitrile (MeCN) and the mixture of acetonitrile and water in 80:20 ratio (MeCN/H2O). Thus, the influence of mobile phase on sorption properties of hydroxyapatite and tricalcium phosphate surface was also discussed.
Highlights
The rapid development of implantology in last decades has triggered to a great deal of research on new materials able to replace injured tissue or even a whole organ
The main purpose of this work was to estimate the properties of hydroxyapatite and β-tricalcium phosphate surface described by e, s, a, b, v parameters of Abraham linear free energy relationship (LFER) model by using inverse liquid chromatography technique
Various descriptors, such as e.g.: Van der Waals volume, connectivity index, partition coefficient, correlation factor, polarizability have been proposed the correlate the retention time, measured for specific probes to physicochemical surface properties of the solid materials under investigation [15,16,17], but the number of papers dealing with application of Inverse liquid chromatography (ILC) to characterization of ceramic biomaterials is limited
Summary
The rapid development of implantology in last decades has triggered to a great deal of research on new materials able to replace injured tissue or even a whole organ This type of materials, called biomaterials, should exhibit biotolerant, non-toxic, non-cancerogenic and non-mutagenic. There are many techniques which can be used in physicochemical characterization of ceramic biomaterials surface, including: FTIR, Raman spectroscopy, X-ray diffraction, contact angle measurements and others [6,7,8]. All these techniques do not enable to observe the influence of the biological environment on biomaterials’ surface. The detailed characterization of the surface layer of biomaterials may be essential, e.g. in the selection of appropriate modifiers of the surface of biomaterial or assessing its ability for cell adhesion
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