Application of intestinal fatty acid binding protein and blood procalcitonin for diagnosis of traumatic intestinal rupture in early stage

Abstract

Objective To investigate the role of intestinal fatty acid binding protein (IFABP) and blood procalcitonin (PCT) in diagnosis of traumatic Intestinal rupture in early stage. Methods The clinical data of 58 patients with abdominal injuries admitted from May 2012 to April 2016 were retrospectively analyzed. All 58 patients were divided into intestinal rupture group (n=21) and non-intestinal rupture group (n=37).The concentrations of IFABP and PCT were detected, analyzed and compared between two groups at different intervals. Results The IFABP and PCT in intestinal rupture group were significantly higher than those in non-intestinal rupture group. The IFABP and PCT in intestinal rupture group significantly decreased after operations. There were significantly differences in IFABP and PCT between two groups at admission, 4 hours after admission, preoperative period, and 24 hours after operation. However, these differences disappeared at 72 hours after operation. At the same time, the accuracy rate 92.4%, sensitivity 96.3%, specificity 72.8% found in combination of these two biomarkers were significantly higher than those of IFABP and PCT measured separately. Conclusions The combination of IFABP and PCT detection can be used as an indicator for the diagnosis of traumatic intestinal rupture in the early stage. Key words: Traumatic intestinal rupture; Intestinal fatty acid binding protein; Blood procalcitonin; Early diagnosis