Application of high-throughput sequencing on gut microbiota for the diagnosis of colorectal cancer

Abstract

Human colorectal cancer (CRC) presents a considerable disease burden worldwide.Besides the genetic factor, gut microbiota could be another important factor resulting in CRC and has become a hot research topic.Along with the increasing accessibility of high-throughput sequencing, the role of structure of microbiota and potential pathogens in colorectal carcinogenesis have become more and more clear.In this review, the recent insights into contributions of the microbiota and candidate CRC-potentiating species to CRC were discussed.Moreover, new findings on the role of candidate pathogens in cancer causation were highlighted.Two pathogenic models were introduced in this review.High-throughput sequencing of gut microbiota will assist us in understanding the pathogenesis of CRC, providing a theoretical basis for disease surveillance.（Chin J Lab Med,2014,37:736-738） Key words: Colorectal neoplasms; Gastrointestinal tract; Microbiota; High-throughput nucleotide sequencing