Abstract
Aim. To study the antidiarrheal activity of enterosorbent on the basis of montmorillonite on the model of serotonin-induced diarrhea.
 Materials and Methods. The study was conducted on laboratory mice of both sexes, acute diarrhea was induced by intraperitoneal injection of serotonin hydrochloride at the dose of 0.32 mg/kg, enterosorbent was introduced orally in the form of aqueous suspension in a wide range of doses 30 minutes before introduction of serotonin. Within 4 hours, the time of onset of diarrhea, the number of defecations, the fluid content in fecal masses were taken into account. Morphological examination of the small intestine was carried out.
 Results. introduction of serotonin led to diarrhea in 100% of animals within 12.8±1.2 minutes, the number of defecations increased 2.5 times as compared to the intact animals and was 19.5±0.5 times in 4 hours, the fecal masses were predominantly semi-liquid and liquid. Use of enterosorbent coded Crim_04 at the maximum dose led to a delay in diarrhea up to 73.6±4.1 minutes, the number of defecations decreased to 9.4±0.1 with a significant solidification of feces. The antidiarrheal effect of enterosorbent was confirmed morphologically.
 Conclusions. Enterosorbent on the basis of montmorillonite with laboratory code Crim_04 possesses a dose-dependent antidiarrheal effect in modeling of serotonin-induced diarrhea.
Highlights
Что применение энтеросорбента Crim-04 в дозе 3320
Вывод Энтеросорбент на основе монтмориллонита под лабораторным шифром Crim_04 обладает дозозависимой противодиарейной активностью при моделировании серотонин-индуцированной диареи
Summary
Применение энтеросорбента под шифром Crim_04 в максимальной используемой дозе приводило к задержке развития диареи до 73,6±4,1 минут, сокращению количества дефекаций до 9,4±0,1 и значительному уплотнению каловых масс. Энтеросорбент на основе монтмориллонита под лабораторным шифром Crim_04 обладает дозозависимой противодиарейной активностью при моделировании серотонин-индуцированной диареи. Цель исследования – провести доклиническое изучение противодиарейной активности энтеросорбента на основе монтмориллонита под лабораторным шифром Crim_04 на модели серотонининдуцированной диареи.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.