Abstract
Objective To explore the value of diffusion kurtosis imaging (DKI) and histogram analysis for assessing preoperative stages and heterogeneity in rectal cancer. Methods Fifty patients with pathologically confirmed rectal adenocarcinoma were enrolled. The value of DKI parameters and histogram metrics for assessing the preoperative stages and heterogeneity in rectal cancer was analyzed retrospectively. Results (1) ADC-10th percentile and ADC-25th percentile were significantly higher in T1-2 than in the T3-4 rectal cancer (the ADC values were 0.65 ± 0.08 × 10−3 mm2/s versus 0.58 ± 0.11 × 10−3 mm2/s and 0.73 ± 0.11 × 10−3 mm2/s versus 0.65 ± 0.11 × 10−3 mm2/s; p values were 0.035 and 0.024, resp.). (2) D-10th percentile and D-25th percentile were also significantly higher in T1-2 than in T3-4 rectal cancer (the D values were 0.96 ± 0.19 × 10−3 mm2/s versus 0.84 ± 0.16 × 10−3 mm2/s and 1.15 ± 0.27 × 10−3 mm2/s versus 0.99 ± 0.18 × 10−3 mm2/s; p values were 0.017 and 0.044, resp.). (3) K value and its histogram metrics showed no statistically significant difference between T1-2 and T3-4. (4) D-10th had the largest area under the curve (AUC 0.799) among all the parameters; the sensitivity and specificity were 84.2 and 61.3%, respectively. (5) DKI combined with traditional MRI had an accuracy of 68% while assessing the lymph node of rectal cancer. Conclusion DKI parameters and histogram metrics are rather valuable in assessing the preoperative stages of rectal cancer; D-10th percentile exhibits the highest diagnostic efficiency.
Highlights
Rectal cancer is one of the most common malignant tumors in the gastrointestinal tract, which accounts for approximately 50%–70% of colorectal cancers
(1) ADC-10th percentile and ADC-25th percentile were significantly higher in T1-2 than in the T3-4 rectal cancer. (2) D-10th percentile and D-25th percentile were significantly higher in T1-2 than in T3-4 rectal cancer. (3) K value and its histogram metrics showed no statistically significant difference between T1-2 and T3-4
Diffusion kurtosis imaging (DKI) parameters and histogram metrics are rather valuable in assessing the preoperative stages of rectal cancer; D-10th percentile exhibits the highest diagnostic efficiency
Summary
Rectal cancer is one of the most common malignant tumors in the gastrointestinal tract, which accounts for approximately 50%–70% of colorectal cancers. Making early and accurate staging to rectal cancer, a vital problem when selecting an appropriate therapeutic method and lowering recurrence, is essential. Magnetic resonance imaging (MRI) examination has the characteristics of noninvasive, multiparameter, and multisequence, which make it the first choice when assessing rectal cancer. Only a few DKI studies with respect to rectal cancer in preoperative staging are yet available, such as prostate cancers, breast cancers, and gliomas [4,5,6]. The present study explored the application of DKI and its histogram for assessing the preoperative stages and heterogeneity of rectal cancer
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
