Abstract
In addition to good biocompatibility, degradable new biomaterials should also have suitable hydrophilic and hydrophobic properties and mechanical strength, and have a degradation rate that matches the tissue growth rate. From the perspective of bionics, a new biodegradable biomaterial was synthesised to fill bone defects in rats, and compared with the autogenous bone transplantation group, blank control group, and polymeric biomaterials to compare the repair effect of bone defects in rats. This study aimed to explore the effect of new biodegradable materials on the repair of bone defects in rats, evaluate the biocompatibility, degradability, bone conduction capacity, osteoinductive capacity and other properties of the material, provide theoretical basis and reference materials for further research and development of the material, and provide new options and ideas for the development of bone defect repair materials. Sixty rat knee joints were used to establish a full-thickness articular cartilage defect model and were randomly divided into three groups. Group A underwent CPM for 8 h each day; group B underwent CPM for 2 h each day. Both groups underwent CPM for 4 weeks, and then caged. Group C were free to move only in the cage. The repair effect of full-thickness articular cartilage defect in group A was better than that in group B and group C. Interventions given to bone defect repair can significantly promote tissue repair, and at the same time promote the recovery of type II collagen and proteoglycans.
Published Version
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