Application of automated flow injection analysis (FIA) to dissolution studies

Abstract

The application of FIA to dissolution studies is described. Propantheline bromide, salicylamide and sulfamethizole were chosen as model drugs to investigate the utility of FIA method for dissolution studies. In each case the FIA system with the appropriate chemistry manifold was coupled with the rotating basket apparatus, A fully automated monitoring of dissolution rates was achieved. A complete dissolution profile in tabulated form is provided by the computer of the system at the end of the experiment. Automation of any type of solid dosage forms agitation technique can be easily acquired by adapting a FIA system.