Application of autofluorescence bronchoscopy during the process of preoperative evaluation of nonsmall cell lung cancer

Abstract

Objective To evaluate the applied value of autofluorescence bronchoscopy (AFB) during the process of the preoperative evaluation of non-small cell lung cancer. Methods 254 patients were classified randomly into white light bronchoscopy ( WLB ) inspection group and AFB inspection group.The positive incisal edge rate of the cancer cells, the positive incisal edge rate of atypical hyperplasia, local recurrence rate and survival rate were compared. Results The positive incisal edge rate ( 1. 9% ) and atypical hyperplasia rate (3. 8% ) in AFB inspection group were significantly lower than in WLB group (5.7% , 23.8% ,x2 =21.755, P ＜0. 05). The local recurrence rate in AFB inspection group (10.4%) was significantly lower than WLB group (38. 5% ,x 2= 23. 692, P ＜ 0. 05). One-, 2- and 3-year survival rate in AFB group (91. 5% , 78. 3% , and 63. 2% ) was significantly higher than in WLB group (69. 7% ,48.4% , 33. 6% ,x2 = 16. 815, 14. 167, 13. 413, P ＜ 0. 05). Conclusion AFB is important during the process of preoperative evaluation of non-small cell lung cancer. It can find the frequent bronchus submucosa transferring of lung cancer and ensure its edge. It can provide the reliable basis for the surgical operation, reduce the local recurrence rate and increase the survival rate. Key words: Bronchoscope; Autofluorescence; Non-small-cell lung carcinoma