Application of Atropine Injection in the Treatment of Ruminant Diseases

Abstract

Atropine is one of the commonly used drugs for clinical treatment of livestock and poultry, as well as one of the commonly used drugs for animal emergency treatment. Its main components are d-hyoscyamine and L-hyoscyamine. Atropine is a toxic colorless, odorless or white crystalline alkaloid extracted from belladonna and other solanaceous plants. It is neutral or weakly acidic when dissolved in water. Atropine is mainly an m-receptor blocker, belonging to anticholinergic drugs. It can compete with acetylcholine for M-choline receptor, thus blocking the M-like effect of acetylcholine. Atropine has a very high selectivity in blocking M receptor, and large doses can also block ganglion N1 receptor. It mainly acts on smooth muscle, relieves small vessel spasm, improves microcirculation, inhibits gland secretion, relieves vagus nerve inhibition on heart, accelerates heart beat, dilates pupils, increases intraocular pressure, excites respiratory center, and relieves respiratory inhibition. It is applied to cases of ruminant diseases such as diarrhea in calves and lambs, toxic diseases in organic phosphorus, abdominal pain caused by parasitic diseases, gastrointestinal volvulus, administration before anesthesia, improvement of microcirculation, eye diseases, etc. through oral, subcutaneous, intramuscular and intravenous injection. However, the amount of treatment has no significant effect on blood vessels and blood pressure. A large dose of treatment can cause skin blood vessels to expand. A large dose of treatment can relieve small vessel spasm when microcirculation is impaired, and expand peripheral blood vessels to improve microcirculation.